Pincer complexes moieties have attracted much attention in the past years. They have
been proved that they are highly active catalysts in many different known transition
metal-catalyzed organic reaction and some unpredictable organic transformation. In this
thesis, we will use PN3P Cobalt pincer complex in two different applications. The first
application is the unpresented Cobalt-catalyzed hydrogenation of nitriles to secondary
The selective hydrogenation of nitriles into secondary imines is a very
challenging task and the catalysts play a very important role in the reaction and the
selectivity. Herein in the thesis, we report the first selective hydrogenation of nitriles to
secondary imines catalyzed by a well-defined and accessible PN3P cobalt pincer
complex. Our results show different selectivity compared with the known PNP cobalt
catalytic system during the nitriles hydrogenation. A set of aliphatic and aromatic nitriles
are hydrogenated to the secondary imine under relatively mild conditions. The second
application is the alkylation of nitriles with alcohols using PN3P cobalt pincer complex.
The alcohol is being used here as alkylating agent in state of using toxic alkyl halides or
excess amount of base to avoid any salt waste. The cobalt pincer complex work as
catalyst for transformation that undergoes alkylation via hydrogen transfer pathways.
The beauty of this reaction that it is delver water as the only byproduct. A different
nitriles and alcohol are tolerated in this reaction.
|Date of Award||Jul 2018|
- Physical Science and Engineering
|Supervisor||Kuo-Wei Huang (Supervisor)|