Mapping of the Co-Transcriptomes of UPEC-Infected Macrophages Reveals New Insights into the Molecular Basis of Host-Pathogen Interactions in Human and Mouse

  • Charalampos Harris Mavromatis

Student thesis: Doctoral Thesis

Abstract

Urinary tract infections (UTI) are among the most common infections in humans. Uropathogenic Escherichia coli (UPEC), the main causative agent of UTIs, can invade and replicate within bladder epithelial cells, and recent evidence demonstrated that some UPEC strains also survive within macrophages. To understand the mechanisms of host subversion that enable UPEC to survive within macrophages, and the contribution of macrophages to UPEC-mediated pathology, I performed host
Date of Award2014
Original languageEnglish
Awarding Institution
  • Biological, Environmental Science and Engineering
SupervisorTimothy Ravasi (Supervisor)

Keywords

  • Co-transcriptome
  • Innate Immunity
  • Uropthogenic E. Coli
  • RNA-Seq
  • Urinary Tract Infection
  • Host-pathogen

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