Well-defined (co)polypeptides bearing pendant alkyne groups

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Abstract

A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of acetylene-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups. This method provides an efficient way to synthesize novel alkyne-functionalized homopolypeptides (A) and copolypeptides, such as AB diblock (B: non-functionalized), ABA triblock and star-AB diblock, as well as linear and star random copolypeptides, precursors of a plethora complex macromolecular architectures by click chemistry.
Original languageEnglish (US)
Pages (from-to)3487-3491
Number of pages5
JournalPolym. Chem.
Volume7
Issue number21
DOIs
StatePublished - 2016

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