Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (R H ) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.
|Original language||English (US)|
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Apr 15 2002|
- Amino acids
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