Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Frédéric Chécot, Sébastien Lecommandoux*, Yves Gnanou, Harm Anton Klok

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

313 Scopus citations

Abstract

Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (R H ) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.

Original languageEnglish (US)
Pages (from-to)1339-1343
Number of pages5
JournalAngewandte Chemie - International Edition
Volume41
Issue number8
DOIs
StatePublished - Apr 15 2002

Keywords

  • Amino acids
  • Copolymers
  • Nanostructures
  • Self-assembly
  • Vesicles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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