Water-soluble dendrimer-poly(ethylene glycol) starlike conjugates as potential drug carriers

Mingjun Liu, Kenji Kono, Jean Frechet

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

The design and synthesis of a new dendrimer-poly(ethylene glycol) (PEG) conjugate that may be used as a model drug carrier are described. The starting material is a polyether dendrimer with two different types of chain end functionalities. The dendritic assembly is made water soluble through attachment of short PEG chains to the dendrimer via one type of functionality. The remaining chain end functionalities then were used to incorporate model drug molecules of varying polarity into the modified dendrimer. Cholesterol and two amino acid derivatives were selected as model drugs for attachment through their respective hydroxyl, carboxylic acid, and amino functional groups to the dendrimer via carbonate, ester, and carbamate linkages. The resulting water-soluble dendrimer-model drug conjugates were characterized by matrix-assisted laser-desorption ionization time of flight (MALDI-TOF) mass spectrometry.

Original languageEnglish (US)
Pages (from-to)3492-3503
Number of pages12
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume37
Issue number17
DOIs
StatePublished - Sep 1 1999

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Water-soluble dendrimer-poly(ethylene glycol) starlike conjugates as potential drug carriers'. Together they form a unique fingerprint.

Cite this