Visible light photoredox-catalyzed multicomponent reactions

Magnus Rueping*, Carlos Vila

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Oxidative three-component reactions for the direct synthesis of α-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp 3 )-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized α-amino amides and imides.

Original languageEnglish (US)
Pages (from-to)2092-2095
Number of pages4
JournalOrganic Letters
Volume15
Issue number9
DOIs
StatePublished - May 3 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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