VIP- and glucagon-induced formation of cyclic AMP in intact retinae in vitro

Michel Schorderet*, Jean Yves Sovilla, Pierre Magistretti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

VIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. VIP was found to be a very potent stimulator of cyclic AMP production in rabbit retina, whereas glucagon was efficient in pigeon retina. Attempts to modify the VIP-induced formation of cyclic AMP by somatostatin or dopamine-related drugs (neuroleptics) were not successful. These biochemical data may be correlated to some extent with the recent immuno-histochemical localisation of VIP and glucagon in mammalian or avian retinae.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalEuropean Journal of Pharmacology
Volume71
Issue number1
DOIs
StatePublished - Apr 24 1981

Keywords

  • Cyclic AMP
  • Glucagon
  • Retina
  • VIP

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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