Unifying metal and Brønsted acid catalysis-concepts, mechanisms, and classifications

Magnus Rueping*, Rene M. Koenigs, Iuliana Atodiresei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

358 Scopus citations

Abstract

Asymmetric catalysis is a key feature of modern synthetic organic chemistry. Traditionally, different combinations of ligands and metals are used to perform highly enantioselective reactions. Since the renaissance of organocatalysis in the early 2000s, tremendous improvement in the field of metal-free catalysis has been achieved. Recently, the combination of transition metals and organocatalysts has allowed the development of new protocols enabling transformations that could not previously be realized. This article aims to present the latest contributions in the field of combined chiral Brønsted acid and metal catalyzed reactions, highlighting the advantages of these catalytic systems as well as describing the uncertainties regarding the molecular structure of the catalytically active species and the reaction mechanisms.

Original languageEnglish (US)
Pages (from-to)9350-9365
Number of pages16
JournalChemistry - A European Journal
Volume16
Issue number31
DOIs
StatePublished - Aug 16 2010

Keywords

  • Asymmetric synthesis
  • Brønsted acids
  • Combined catalysis
  • Domino reactions
  • Organocatalysis
  • Transition metals

ASJC Scopus subject areas

  • Chemistry(all)

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