Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

Yongwu Peng, Ying Huang, Yihan Zhu, Bo Chen, Liying Wang, Zhuangchai Lai, Zhicheng Zhang, Meiting Zhao, Chaoliang Tan, Nailiang Yang, Fangwei Shao, Yu Han, Hua Zhang

Research output: Contribution to journalArticlepeer-review

231 Scopus citations

Abstract

The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C3v molecular symmetry as building units, a novel imine-linked COF, namely TPA-COF, with hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e. the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs are used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.
Original languageEnglish (US)
Pages (from-to)8698-8704
Number of pages7
JournalJournal of the American Chemical Society
Volume139
Issue number25
DOIs
StatePublished - Jun 15 2017

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