Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering

Archana Mishra, Yihua Loo, Rensheng Deng, Yon Jin Chuah, Hwan Tak Hee, Jackie Y. Ying, Charlotte Hauser

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

A new class of systematically designed ultrasmall (tri- to heptamer) peptides presents the smallest natural, non-aromatic structures that self-assemble in water to hydrogels. The peptide motif consists of an aliphatic amino acid tail of decreasing hydrophobicity capped by a polar head. The fibrous scaffolds assemble from nanostructured aggregates to condensed three-dimensional (3D) meshes, entrapping up to 99.9% water and resembling collagen fibers in the extracellular matrix. The resulting hydrogels are biocompatible, heat resistant up to 90°C and demonstrate tunable, high mechanical strength. Given their facile and cost-effective synthesis, these new materials would be attractive for applications ranging from injectable medical therapies to tissue-engineered scaffolds.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalNano Today
Volume6
Issue number3
DOIs
StatePublished - Jun 1 2011

Keywords

  • Hydrogels
  • Self-assembly
  • Tissue engineering
  • Ultrasmall peptides

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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