Ultrashort Peptide Theranostic Nanoparticles by Microfluidic-Assisted Rapid Solvent Exchange

Ming Ni, Guillaume Tresset, Ciprian Iliescu, Charlotte Hauser

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Ultrashort peptides (USPs), composed of three to seven amino acids, can self-assemble into nanofibers in pure water. Here, using hydrodynamic focusing and a solvent exchange method on a microfluidic setup, we convert these nanofibers into globular nanoparticles with excellent dimensional control and polydispersity. Thanks to USP nanocarriers' structure, different drugs can be loaded. We used Curcumin as a model drug to evaluate the performance of USP nanocarriers as a novel drug delivery vehicle. These nanoparticles can efficiently cross the cell membrane and possess nonlinear optical properties. Therefore, we envisage USP nanoparticles as promising future theranostic nanocarriers.
Original languageEnglish (US)
Pages (from-to)627-632
Number of pages6
JournalIEEE Transactions on Nanobioscience
Volume19
Issue number4
DOIs
StatePublished - Jul 3 2020

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