Three-dimensionally two-photon lithography realized vascular grafts.

Tania Limongi, Laura Brigo, Luca Tirinato, Francesca Pagliari, Alessandro Gandin, Paolo Contessotto, Andrea Giugni, Giovanna Brusatin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Generation of artifical vascular grafts (TEVG) as blood vessel substitutes is a primary challenge in biomaterial and tissue engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behaviour to withstand the pressure exerted by blood flow.
Original languageEnglish (US)
JournalBiomedical materials (Bristol, England)
DOIs
StatePublished - Nov 13 2020

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