Thieme chemistry journal awardees - Where are they now? Asymmetric br?nsted acid catalyzed transfer hydrogenations

Magnus Rueping*, Erli Sugiono, Fenja R. Schoepke

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

Asymmetric hydrogenations are of great importance in the synthesis of optically active amines. This account highlights the development of the first metal-free transfer hydrogenation that is both highly enantioselective and inspired by natures dehydrogen?ase. Further focus is given to the extension of this bioinspired process to provide a variety of valuable, biologically active products and natural products under mild reaction conditions.

Original languageEnglish (US)
Pages (from-to)852-865
Number of pages14
JournalSynlett
Issue number6
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Asymmetric reduction
  • Binol phosphate
  • Br?nsted acid
  • Hantzsch ester
  • Organocatalysis
  • Transfer hydrogenation

ASJC Scopus subject areas

  • Organic Chemistry

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