Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

Zhuang Han, Yong-Xin Li, Ling-Li Liu, Liang Lu, Xianrong Guo, Xixiang Zhang, Xiao-Yong Zhang, Shu-Hua Qi, Ying Xu, Pei-Yuan Qian

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Abstract

Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
Original languageEnglish (US)
Pages (from-to)128
JournalMarine Drugs
Volume15
Issue number5
DOIs
StatePublished - Apr 29 2017

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