More stringent emission regulations call for high-efficiency engines in the heavy-duty vehicle sector. Towards this goal, reduced heat losses, as well as increased work output, are needed. In this study, a multiple injector concept to control the combustion as well as reduce the hot boundary zones is proposed. Earlier studies have proven that multiple injectors experience lower heat losses and higher efficiency. However, a comprehensive investigation of the causes for experimental heat loss was not performed in depth. Experiments in a heavy-duty CI engine equipped with three injectors were thus performed. Engine configurations of single, dual and triple injectors were compared for a single-injection case as well as a multi-injection (Sabathe-cycle) case. Heat losses, efficiency and the emission levels were quantified and investigated. Optical experiments were performed to investigate the temperature field as well as flame behavior. This led to further understanding of the heat loss drivers. Experimental data was coupled with the double compression expansion engine concept for waste heat recovery, utilizing the energy from reduced heat losses. Notable findings included an efficiency increase of 1.9 %-points when using all three injectors for a single injection. Three injectors improved the efficiency an additional 1.2 %-points in a Sabathe-cycle case as compared to a single injector case. These gains mainly followed by reduced heat losses caused by hot zones being kept away from the boundaries. Thus, the benefits of multiple injectors were proven.