The time machine: A simulation approach for stochastic trees

Ajay Jasra, Maria De Iorio, Marc Chadeau-Hyam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

In this paper, we consider a simulation technique for stochastic trees. One of the most important areas in computational genetics is the calculation and subsequent maximization of the likelihood function associated with such models. This typically consists of using importance sampling and sequential Monte Carlo techniques. The approach proceeds by simulating the tree, backward in time from observed data, to a most recent common ancestor. However, in many cases, the computational time and variance of estimators are often too high to make standard approaches useful. In this paper, we propose to stop the simulation, subsequently yielding biased estimates of the likelihood surface. The bias is investigated from a theoretical point of view. Results from simulation studies are also given to investigate the balance between loss of accuracy, saving in computing time and variance reduction. © 2011 The Royal Society.
Original languageEnglish (US)
Title of host publicationProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
DOIs
StatePublished - Aug 8 2011
Externally publishedYes

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