TY - JOUR
T1 - The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche
AU - Aida, Mitsuhiro
AU - Beis, Dimitris
AU - Heidstra, Renze
AU - Willemsen, Viola
AU - Blilou, Ikram
AU - Galinha, Carla
AU - Nussaume, Laurent
AU - Noh, Yoo Sun
AU - Amasino, Richard
AU - Scheres, Ben
PY - 2004/10/1
Y1 - 2004/10/1
N2 - A small organizing center, the quiescent center (QC), maintains stem cells in the Arabidopsis root and defines the stem cell niche. The phytohormone auxin influences the position of this niche by an unknown mechanism. Here, we identify the PLETHORA1 (PLT1) and PLT2 genes encoding AP2 class putative transcription factors, which are essential for QC specification and stem cell activity. The PLT genes are transcribed in response to auxin accumulation and are dependent on auxin response transcription factors. Distal PLT transcript accumulation creates an overlap with the radial expression domains of SHORT-ROOT and SCARECROW, providing positional information for the stem cell niche. Furthermore, the PLT genes are activated in the basal embryo region that gives rise to hypocotyl, root, and root stem cells and, when ectopically expressed, transform apical regions to these identities. Thus, the PLT genes are key effectors for establishment of the stem cell niche during embryonic pattern formation.
AB - A small organizing center, the quiescent center (QC), maintains stem cells in the Arabidopsis root and defines the stem cell niche. The phytohormone auxin influences the position of this niche by an unknown mechanism. Here, we identify the PLETHORA1 (PLT1) and PLT2 genes encoding AP2 class putative transcription factors, which are essential for QC specification and stem cell activity. The PLT genes are transcribed in response to auxin accumulation and are dependent on auxin response transcription factors. Distal PLT transcript accumulation creates an overlap with the radial expression domains of SHORT-ROOT and SCARECROW, providing positional information for the stem cell niche. Furthermore, the PLT genes are activated in the basal embryo region that gives rise to hypocotyl, root, and root stem cells and, when ectopically expressed, transform apical regions to these identities. Thus, the PLT genes are key effectors for establishment of the stem cell niche during embryonic pattern formation.
UR - http://www.scopus.com/inward/record.url?scp=16544369949&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2004.09.018
DO - 10.1016/j.cell.2004.09.018
M3 - Article
C2 - 15454085
AN - SCOPUS:16544369949
VL - 119
SP - 109
EP - 120
JO - Cell
JF - Cell
SN - 0092-8674
IS - 1
ER -