The path from β-carotene to carlactone, a strigolactone-like plant hormone

Adrian Alder, Muhammad Jamil, Mattia Marzorati, Mark Bruno, Martina Vermathen, Peter Bigler, Sandro Ghisla, Harro Bouwmeester, Peter Beyer, Salim Al-Babili*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

496 Scopus citations

Abstract

Strigolactones, phytohormones with diverse signaling activities, have a common structure consisting of two lactones connected by an enol-ether bridge. Strigolactones derive from carotenoids via a pathway involving the carotenoid cleavage dioxygenases 7 and 8 (CCD7 and CCD8) and the iron-binding protein D27. We show that D27 is a β-carotene isomerase that converts all-trans-β-carotene into 9-cis-β-carotene, which is cleaved by CCD7 into a 9-cis - configured aldehyde. CCD8 incorporates three oxygens into 9-cis-β-apo-10′-carotenal and performs molecular rearrangement, linking carotenoids with strigolactones and producing carlactone, a compound with strigolactone-like biological activities. Knowledge of the structure of carlactone will be crucial for understanding the biology of strigolactones and may have applications in combating parasitic weeds.

Original languageEnglish (US)
Pages (from-to)1348-1351
Number of pages4
JournalScience
Volume335
Issue number6074
DOIs
StatePublished - Mar 16 2012

ASJC Scopus subject areas

  • General

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