The metallacrowns as templates for spontaneous self-assembly of polypeptides into a tetrahelical bundle

Marta Cal, Łukasz Jaremko, Mariusz Jaremko, Piotr Stefanowicz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Amphiphilic peptide sequences with β-aminohydroxamic acid (βahx) at their C-termini were complexed with Cu2+ ions resulting in formation of stable metallacrowns composed of βahx and copper. The ESI-MS data for the obtained compounds show formation of supramolecular structures of MW approx. 7000 Da with the compositions corresponding to metallacrowns. The addition of Cu2+ to a solution of βahx-containing peptides results in distinct changes in the CD spectra indicating a shift of their conformational equilibria toward helical structures. The experiments with enzymatic hydrolysis show that formation of metallacrown systems significantly increases the proteolytic stability of investigated peptides.

Original languageEnglish (US)
Pages (from-to)3770-3777
Number of pages8
JournalNew Journal of Chemistry
Volume37
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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