The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids

Pierre Magistretti*, Patrick Hof, Michel Schorderet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.

Original languageEnglish (US)
Pages (from-to)751-753
Number of pages3
JournalNeurochemistry International
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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