The importomer-A peroxisomal membrane complex involved in protein translocation into the peroxisome matrix

Naganand Rayapuram, Suresh Subramani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The import of proteins into the peroxisome matrix is an essential step in peroxisome biogenesis, which is critical for normal functioning of most eukaryotic cells. The translocation of proteins across the peroxisome membrane and the dynamic behavior of the import receptors during the import cycle is facilitated by several peroxisome-membrane-associated protein complexes, one of which is called the importomer complex [B. Agne, N.M. Meindl, K. Niederhoff, H. Einwachter, P. Rehling, A. Sickmann, H.E. Meyer, W. Girzalsky, W.H. Kunau, Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery, Mol. Cell 11 (2003) 635-646; P.P. Hazra, I. Suriapranata, W.B. Snyder, S. Subramani, Peroxisome remnants in pex3Δ cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes, Traffic 3 (2002) 560-574. [1,2]]. We provide below a brief historical perspective regarding the importomer and its role in peroxisome biogenesis. We also identify areas in which further work is needed to uncover the physiological role of the importomer.

Original languageEnglish (US)
Pages (from-to)1613-1619
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1763
Issue number12
DOIs
StatePublished - Dec 1 2006

Keywords

  • Docking and RING subcomplexes
  • Importomer
  • Peroxisomal matrix protein import

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

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