The genome of the model beetle and pest Tribolium castaneum

Stephen Richards*, Richard A. Gibbs, George M. Weinstock, Susan J. Brown, Robin Denell, Richard W. Beeman, Richard Gibbs, Gregor Bucher, Markus Friedrich, Cornelis J.P. Grimmelikhuijzen, Martin Klingler, Marce Lorenzen, Siegfried Roth, Reinhard Schröder, Diethard Tautz, Evgeny M. Zdobnov, Donna Muzny, Tony Attaway, Stephanie Bell, Christian J. BuhayMimi N. Chandrabose, Dean Chavez, Kerstin P. Clerk-Blankenburg, Andrew Cree, Marvin Dao, Clay Davis, Joseph Chacko, Huyen Dinh, Shannon Dugan-Rocha, Gerald Fowler, Toni T. Garner, Jeffrey Garnes, Andreas Gnirke, Alica Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N. Jhangiani, Vandita Joshi, Ziad Mohid Khan, Laronda Jackson, Christie Kovar, Andrea Kowis, Sandra Lee, Lora R. Lewis, Jon Margolis, Margaret Morgan, Lynne V. Nazareth, Ngoc Nguyen, Geoffrey Okwuonu, David Parker, San Juana Ruiz, Jireh Santibanez, Joël Savard, Steven E. Scherer, Brian Schneider, Erica Sodergren, Selina Vattahil, Donna Villasana, Courtney S. White, Rita Wright, Yoonseong Park, Jeff Lord, Brenda Oppert, Liangjiang Wang, George Weinstock, Yue Liu, Kim Worley, Christine G. Elsik, Justin T. Reese, Eran Elhaik, Giddy Landan, Dan Graur, Peter Arensburger, Peter Atkinson, Jim Beidler, Jeffery P. Demuth, Douglas W. Drury, Yu Zhou Du, Haruhiko Fujiwara, Vincenza Maselli, Mizuko Osanai, Hugh M. Robertson, Zhijian Tu, Jian Jun Wang, Suzhi Wang, Henry Song, Lan Zhang, Doreen Werner, Mario Stanke, Burkhard Morgenstern, Victor Solovyev, Peter Kosarev, Garth Brown, Hsiu Chuan Chen, Olga Ermolaeva, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, Donna Maglott, Kim Pruitt, Victor Sapojnikov, Alexandre Souvorov, Aaron J. Mackey, Robert M. Waterhouse, Stefan Wyder, Evgenia V. Kriventseva, Tatsuhiko Kadowaki, Peer Bork, Manuel Aranda, Riyue Bao, Anke Beermann, Nicola Berns, Renata Bolognesi, François Bonneton, Daniel Bopp, Thomas Butts, Arnaud Chaumot, Robin E. Denell, David E.K. Ferrier, Cassondra M. Gordon, Marek Jindra, Que Lan, H. Michael G. Lattorff, Vincent Laudet, Cornelia Von Levetsow, Zhenyi Liu, Rebekka Lutz, Jeremy A. Lynch, Rodrigo Nunes Da Fonseca, Nico Posnien, Rolf Reuter, Johannes B. Schinko, Christian Schmitt, Michael Schoppmeier, Teresa D. Shippy, Franck Simonnet, Henrique Marques-Souza, Yoshinori Tomoyasu, Jochen Trauner, Maurijn Van Der Zee, Michel Vervoort, Nadine Wittkopp, Ernst A. Wimmer, Xiaoyun Yang, Andrew K. Jones, David B. Sattelle, Paul R. Ebert, David Nelson, Jeffrey G. Scott, Subbaratnam Muthukrishnan, Karl J. Kramer, Yasuyuki Arakane, Qingsong Zhu, David Hogenkamp, Radhika Dixit, Haobo Jiang, Zhen Zou, Zhiqiang Lu, Jeremy Marshall, Niranji Sumathipala, Elena Elpidina, Cris Oppert, Jay Evans, Boran Altincicek, Andreas Vilcinskas, Michael Williams, Dan Hultmark, Charles Hetru, Frank Hauser, Giuseppe Cazzamali, Michael Williamson, Bin Li, Yoshiaki Tanaka, Reinhard Predel, Susanne Neupert, Joachim Schachtner, Peter Verleyen, Florian Raible, Kimberly K.O. Walden, Sergio Angeli, Sylvain Forêt, Stefan Schuetz, Ryszard Maleszka, Sherry C. Miller, Daniela Grossmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

888 Scopus citations

Abstract

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalNature
Volume452
Issue number7190
DOIs
StatePublished - Apr 24 2008

ASJC Scopus subject areas

  • General

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