The first general, efficient and highly enantioselective reduction of quinoxalines and quinoxalinones

Magnus Rueping*, Francisco Tato, Fenja R. Schoepke

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

(Chemical Equation Presented) Simple yet efficient: A series of diverse substituted tetrahydroquinoxalines and dihydroquinoxalinones have been synthesized for the first time in a highly enantioselective fashion (see scheme). Using this metalfree hydrogenation it is possible to isolate these products, which are of high pharmaceutical interest, in good yields and with excellent enantioselectivities in a minimal number of reaction steps.

Original languageEnglish (US)
Pages (from-to)2688-2691
Number of pages4
JournalChemistry - A European Journal
Volume16
Issue number9
DOIs
StatePublished - Mar 1 2010

Keywords

  • Brønsted acid
  • Hantzsch ester
  • Organocatalysis
  • Pyrazine
  • Pyridine
  • Transfer hydrogenation

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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