The evolutionary rate of a protein is influenced by features of the interacting partners

Takashi Makino*, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.

Original languageEnglish (US)
Pages (from-to)784-789
Number of pages6
JournalMolecular biology and evolution
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Evolution
  • Functional module
  • Protein-protein interaction
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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