The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization

Katarzyna Kapczyńska, Piotr Stefanowicz*, Lukasz Jaremko, Mariusz Jaremko, Alicja Kluczyk, Zbigniew Szewczuk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes 2H, 13C and 18O.

Original languageEnglish (US)
Pages (from-to)923-932
Number of pages10
JournalAmino Acids
Volume40
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • Amadori rearrangement
  • C
  • Fructose
  • Glucose
  • Glycation
  • H
  • Isotopes
  • Labeling
  • Microwave synthesis
  • NMR studies
  • Non-enzymatic protein modifications
  • O
  • Peptides
  • Regioselective

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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