The effect of Cytochalasin D on F-Actin behavior of single-cell electroendocytosis using multi-chamber micro cell chip

Ran Lin, Donald C. Chang, Yi-Kuen Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytochalasin D (CD) on the actin-filaments (F-Actin) behavior of single-cell EED. The CD concentration (C CD) can control the depolymerization of F-actin. A multi-chamber micro cell chip was fabricated to study the EED under different conditions. Large-scale single-cell data demonstrated EED highly depends on both electric field and C CD. © 2012 IEEE.
Original languageEnglish (US)
Title of host publication2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages150-153
Number of pages4
ISBN (Print)9781467311243
DOIs
StatePublished - Mar 2012
Externally publishedYes

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