The Central Role of Astrocytes in Neuroenergetics

Luc Pellerin*, Pierre J. Magistretti

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

This chapter reviews astrocyte function in the maintenance metabolic homeostasis. Astrocytes play essential roles in coupling neuronal activity to energy metabolism, both through their participation in the glutamate/glutamine cycle and by providing lactate to neurons as an additional energy substrate in register with increased activity. It also appears that astrocytes participate in coupling neuronal activity to blood flow. Such findings are important not only for the understanding of fundamental aspects of brain functions, but also for the use of functional brain imaging techniques that rely on metabolic and vascular parameters to map cognitive processes.

Original languageEnglish (US)
Title of host publicationNeuroglia
PublisherOxford University Press
ISBN (Electronic)9780199865024
ISBN (Print)0195152220, 9780195152227
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Keywords

  • Astrocyte
  • Glutamate
  • Glutamine cycle
  • Metabolic homeostasis
  • Neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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