The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, Manoj Vasisht Mane, Steven P. Nolan, Fabiano Visentin

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Abstract

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.
Original languageEnglish (US)
JournalChemical communications (Cambridge, England)
DOIs
StatePublished - Sep 14 2020

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  • CCDC 2006223: Experimental Crystal Structure Determination

    Scattolin, T. (Creator), Bortolamiol, E. (Creator), Palazzolo, S. (Creator), Caligiuri, I. (Creator), Perin, T. (Creator), Canzonieri, V. (Creator), Demitri, N. (Creator), Rizzolio, F. (Creator), Cavallo, L. (Creator), Dereli, B. (Creator), Mane, M. V. (Creator), Nolan, S. P. (Creator), Visentin, F. (Creator), Scattolin, T. (Creator), Bortolamiol, E. (Creator), Palazzolo, S. (Creator), Caligiuri, I. (Creator), Perin, T. (Creator), Canzonieri, V. (Creator), Demitri, N. (Creator), Rizzolio, F. (Creator), Mane, M. V. (Creator), Nolan, S. P. (Creator) & Visentin, F. (Creator), Cambridge Crystallographic Data Centre, Sep 14 2020

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