The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, Manoj Vasisht Mane, Steven P. Nolan, Fabiano Visentin

Research output: Contribution to journalArticlepeer-review

Abstract

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.
Original languageEnglish (US)
JournalChemical communications (Cambridge, England)
DOIs
StatePublished - Sep 14 2020

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