The antibacterial activity of syringopicroside, its metabolites and natural analogues from syringae folium

Zhengyuan Zhou, Na Han, Zhihui Liu, Zehai Song, Peng Wu, Jingxuan Shao, Jiaming Zhang, Jun Yin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In the present study, the in vitro antibacterial activity of an effective fraction (ESF) from Syringae Folium (SF) on Methicillin-resistant Staphylococcus aureus (MRSA) was evaluated and then its in vivo activity was evaluated by using the MRSA-infected mouse peritonitis model. The ESF showed a significant in vitro and in vivo activity on decreasing the Minimum Inhibitory Concentrations (MICs) and increasing the survival rate of mouse from 42.8% to 100%. Six iridoid glucosides (IGs) of ESF were characterized by UPLC-TOF-MS method and also isolated by column chromatography. Most of them showed in vitro anti MRSA activity. Syringopicroside (Sy), the major compound of IGs, was found to increase the survival rate from 42.8% to 92.8% of the MRSA-infected mouse, which revealed Sy is also the main active components of ESF. In order to know why the effect of oral administration of SF is better than its injections in clinic and the metabolites of Sy, seven metabolites of Sy were isolated from rat urine and identified on the basis of NMR and MS spectra. Most of metabolites possessed stronger in vitro anti-MRSA activity than that of Sy, which furtherly proved the clinical result.
Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalFitoterapia
Volume110
DOIs
StatePublished - Feb 18 2016

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Fingerprint

Dive into the research topics of 'The antibacterial activity of syringopicroside, its metabolites and natural analogues from syringae folium'. Together they form a unique fingerprint.

Cite this