Targeted cancer cell death induced by biofunctionalized magnetic nanowires

Maria F. Contreras, Timothy Ravasi, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.
Original languageEnglish (US)
Title of host publication2nd Middle East Conference on Biomedical Engineering
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages47-50
Number of pages4
ISBN (Print)9781479947997
DOIs
StatePublished - Feb 2014

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