Talk is cheap - Cross-talk in establishment, maintenance, and readout of chromatin modifications

Wolfgang Fischle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (pp. 3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.

Original languageEnglish (US)
Pages (from-to)3375-3382
Number of pages8
JournalGenes and Development
Volume22
Issue number24
DOIs
StatePublished - Dec 15 2008

Keywords

  • DNA methylation
  • Histone H3 Ser 10 phosphorylation
  • Histone H3 mutation
  • Neurospora crassa
  • Protein phosphatase PP1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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