Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery

Valentina Carboni, Carine Maaliki, Mram Z. Alyami, Shahad K. Alsaiari, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

Abstract

Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated 9 (Cas-9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non-viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self-assembled non-viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.
Original languageEnglish (US)
Pages (from-to)1800085
JournalAdvanced Therapeutics
Volume2
Issue number4
DOIs
StatePublished - Feb 10 2019

Fingerprint Dive into the research topics of 'Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery'. Together they form a unique fingerprint.

Cite this