Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation

Kewal Kumar, Sunil Sagar, Luke Esau, Mandeep Kaur, Vipan Kumar

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The present manuscript describes the synthesis of uracil-isatin hybrids via azide-alkyne cycloadditions and their cytotoxic evaluation against three human cancer cell lines viz. HeLa (cervix), MCF-7 (breast) and DU145 (prostate) using MTT assay. The evaluation studies revealed the dependence of cytotoxicity on C-5 substituents of both uracil and isatin as well as the alkyl chain length with compounds 6g and 6k showing IC50 values 18.21 and 13.90 μM respectively against DU145 cell lines. Most of the synthesized conjugates exhibited considerable selectivity against MCF-7 and DU145 cell lines. © 2012 Elsevier Masson SAS. All rights reserved.
Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume58
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Fingerprint

Dive into the research topics of 'Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation'. Together they form a unique fingerprint.

Cite this