Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

Liang-Feng Yao, Yuan Wang, Kuo-Wei Huang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A convenient and efficient synthetic method for the construction of morpholine and piperazine derivatives in moderate to good yields was established. The reaction proceeds smoothly with 1.0 mol% gold catalyst loading. A plausible mechanism involving the cascade cyclization and isomerizations to produce the six-membered ring was proposed and supported by deuterium labeling experiments.
Original languageEnglish (US)
Pages (from-to)721-725
Number of pages5
JournalOrganic Chemistry Frontiers
Volume2
Issue number6
DOIs
StatePublished - Apr 20 2015

ASJC Scopus subject areas

  • Organic Chemistry

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