Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines

Alan R. Katritzky*, Nivine Khachab, Sergey Bobrov, Megumi Yoshioka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl- methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N′-hydroxy-1H-1,2,3- benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.

Original languageEnglish (US)
Pages (from-to)6753-6758
Number of pages6
JournalJournal of Organic Chemistry
Volume71
Issue number18
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Organic Chemistry

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