Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation

Farhat Batool, Shehla Parveen, Abdul-Hamid M. Emwas, Salim Sioud, Xin Gao, Munawar A. Munawar, Ghayoor A. Chotana

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11 Scopus citations

Abstract

The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.
Original languageEnglish (US)
Pages (from-to)4256-4259
Number of pages4
JournalOrganic Letters
Volume17
Issue number17
DOIs
StatePublished - Aug 17 2015

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