Synthesis of E-aryl ethenesulfonamides: A simple one-pot, two-step procedure from 1-hydroxy-1-arylalkanes

Andrea Aramini*, Maria C. Cesta, Silvia Coniglio, Christian Bijani, Sandro Colagioia, Valerio D Elia, Marcello Allegretti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The unusual reactivity of 1-phenyl-1-ethane-sulfonic acid in thionyl chloride was investigated. Mechanistic considerations led us to set up a new and efficient synthesis of E-arylethenesulfonamides starting from 1-hydroxy-1-arylalkanes. The easy availability of the starting materials and the straightforward, one-pot procedure make this process an attractive method for the preparation of these compounds currently largely employed in chemical and pharmaceutical fields.

Original languageEnglish (US)
Pages (from-to)7911-7914
Number of pages4
JournalJournal of Organic Chemistry
Volume68
Issue number20
DOIs
StatePublished - Oct 3 2003

ASJC Scopus subject areas

  • Organic Chemistry

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