Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery

Shuaipeng Wang, Xiaowan Song, Xiaoshuang Feng, Peng Chen, Jiasheng Qian, Ru Xia, Jibin Miao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalChinese Journal of Chemical Physics
Volume27
Issue number5
DOIs
StatePublished - Oct 27 2014

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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