Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

Xiangqian Liu, Huifeng Yue, Jiaqi Jia, Lin Guo, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.

Original languageEnglish (US)
Pages (from-to)11771-11775
Number of pages5
JournalChemistry - A European Journal
Volume23
Issue number49
DOIs
StatePublished - Sep 4 2017

Keywords

  • C−N activation
  • amide
  • amine
  • nickel catalysis
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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