Synthesis of acid-sensitive latices by ring-opening metathesis polymerization

Damien Quémener, Valérie Héroguez*, Yves Gnanou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

This study describes the synthesis of polynorbornene colloidal particles able to release active molecules in response to pH change. Such functionalized polynor-bornene latices with surface active molecules have been obtained by ring-opening metathesis copolymerization in a dichloromethane/ethanol medium in the presence of α-norbornenyl poly(ethylene oxide) macromonomer. Two different strategies of intro duction of the active molecule-either at their periphery or at their core - have been contemplated. The particles have been characterized by both dynamic light scattering and transmission electron microscopy. Their size was found to range from 260 to 600 nm. The release of the active molecules was monitored by UV spectrometry. After 48 h in an appropriate HCl buffer (pH = 3) more than 80% of the initially linked active molecule was released.

Original languageEnglish (US)
Pages (from-to)217-229
Number of pages13
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Dispersion polymerization
  • Drug delivery systems; latices
  • Functionalized latices
  • Ring-opening metathesis polymerization
  • ROMP

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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