Synthesis of 3-fluoro-3-aryl oxindoles: Direct enantioselective α arylation of amides

Linglin Wu, Laura Falivene, Emma E. Drinkel, Sharday Grant, Anthony Linden, Luigi Cavallo, Reto Dorta

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Modus operandi: Catalytic access to the title compounds through a new asymmetric α-arylation protocol is reported (see scheme). These products are formed in good yields and excellent enantioselectivities by using a new and easily synthesized chiral N-heterocyclic carbene (NHC) ligand. Advanced DFT calculations reveal the properties of the NHC ligand and the mode of operation of the catalyst. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish (US)
Pages (from-to)2870-2873
Number of pages4
JournalAngewandte Chemie International Edition
Volume51
Issue number12
DOIs
StatePublished - Feb 6 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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