Synthesis of 3- and 4- Arm star-block copolypeptides using multifunctional amino initiators and high vacuum techniques

Thrasyvoulos Aliferis, Hermis Iatrou, Nikos Hadjichristidis*, Jamie Messman, Jimmy Mays

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Three- and four-arm star-block copolypeptides, (BL-b-G)3 and (G-b-BL)4, of poly(ε-butyloxycarbonyl-L-lysine) (BL) and poly(γ-benzyl-L-glutamate) (G), were synthesized under high vacuum conditions, using three different multifunctional aminoinitiators for the ring opening polymerization of the corresponding α-aminoacid N-carboxyanhydrides. When the initiator contained only primary amine groups {2(aminomethyl)-2-methyl-1,3-propanediamine, AMPDA}, well-defined star-block copolypeptides with monomodal molecular weight distribution were produced. However, if the multifunctional initiator contained both primary and tertiary amine groups {polypropylenimine tetraamine dendrimer, generation 1.0 (DAB); amidoethylethanolamine dendrimer, 1,4-diaminobutane core, generation 0.0 (PAMAM)}, bimodal high polydispersed copolypeptides were formed. The different behaviors are due to the participation of both the primary and tertiary amino groups, each following different polymerization kinetics.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalMacromolecular Symposia
Volume240
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • α-aminoacid N-carboxyanhydrites
  • Biopolymers
  • Living ring opening polymerization
  • Multifunctional amine initiators
  • Star polymers

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics

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