Synthesis and structural investigations of a a-hydroxylated b-hexapeptide

Francois Gessier, Magnus Rueping, Dieter Seebach

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


(2S,3S)-a-Hydroxy-b3-Hleu, -b3-HAla and -b3-HVal-amino acids were prepd. and used for the synthesis of a b-hexapeptide. The resulting a-hydroxylated-b3-hexapeptide (terminally protected) and its fully deprotected form are insol. in most org. solvents including MeOH and fluorinated alcs., suggesting that they form aggregates or that they adopt a sheet-like conformation. Their phys. properties prevented any CD spectroscopic investigations and limited the possibilities of NMR spectroscopy. [on SciFinder (R)]
Original languageEnglish (US)
Title of host publicationSynthesis and structural investigations of a a-hydroxylated b-hexapeptide
Number of pages2
StatePublished - 2002
Externally publishedYes

Publication series

NamePeptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002


  • ACID
  • Chemical
  • FORM
  • NMR
  • NMR Spectroscopy
  • Peptides
  • Proteins
  • Solvents
  • Structural
  • Synthesis
  • beta hexapeptide alpha hydroxy beta amino acid syn

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