Synthesis and conformations of dendronized poly(L-lysine)

Cameron C. Lee, Jean M J Fréchet

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Dendronized polymers based on a poly(L-lysine) backbone have been synthesized up to the fourth generation. The hydroxyl-terminated polymers are completely water-soluble, which makes them good candidates for drug delivery applications. The dendronized polypeptide backbones are helical at lower generations, but undergo a dramatic conformational change from α-helical to disordered upon increasing the dendron size to the third generation. This conformational change, attributed to steric repulsions between dendrons, is supported by spectroscopic measurements, while chain extension upon dendronization is confirmed by scanning force microscopy.

Original languageEnglish (US)
Pages (from-to)476-481
Number of pages6
JournalMacromolecules
Volume39
Issue number2
DOIs
StatePublished - Jan 24 2006
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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