Suzuki-Miyaura cross-coupling coupling reactions with low catalyst loading: A green and sustainable protocol in pure water

Aziz Fihri, Denis Luart, Christophe Len, Abderrahim Solhy, Carole Chevrin, Vivek Polshettiwar

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

The Suzuki-Miyaura coupling reaction represents one of the most important synthetic transformations developed in the 20th century. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance, and benign water as a reaction medium was found to be highly effective to overcome some of these issues. In the present manuscript, we described Suzuki-Miyaura coupling reactions in neat water, without using any phase transfer reagent. Notably, this protocol also works with ultra-low loading of catalyst with high turnover numbers and also able to couple challenging substrates like aryl chlorides. © 2011 The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)3116
JournalDalton Transactions
Volume40
Issue number13
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Inorganic Chemistry

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