Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis

Yoon Kyung Jang, Tobias Krückel, Magnus Rueping, Osama El-Sepelgy

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The first example of manganese-catalyzed C-alkylation of the carboxylic acid derivatives is reported. The bench-stable homogeneous manganese complex enables the transformation of the renewable alcohol and carboxylic acid derivative feedstock to higher value esters and amides. The reaction operates via hydrogen autotransfer and ideally produces water as the only side product. Importantly, aliphatic-, benzylic-, and heterocyclic-containing alcohols can be used as alkylating reagents, eliminating the need for mutagenic alkyl halides.
Original languageEnglish (US)
Pages (from-to)7779-7783
Number of pages5
JournalOrganic Letters
Volume20
Issue number24
DOIs
StatePublished - Dec 3 2018

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