Strategies for developing pH sensitive fluorescent probes

Mikhail Y. Berezin, Kevin Guo, Hyeran Lee, Walter Akers, Adah Almutairi, Jean M J Fréchet, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

Original languageEnglish (US)
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Volume7576
DOIs
StatePublished - 2010
Externally publishedYes
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II - San Francisco, CA, United States
Duration: Jan 25 2010Jan 27 2010

Other

OtherReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
CountryUnited States
CitySan Francisco, CA
Period01/25/1001/27/10

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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