Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses

Yasuo Ina*, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

To examine whether positive selection operates on the hemagglutinin 1 (HA1) gene of human influenza A viruses (H1 subtype), 21 nucleotide sequences of the HA1 gene were statistically analyzed. The nucleotide sequences were divided into antigenic and nonantigenic sites. The nucleotide diversities for antigenic and nonantigenic sites of the HA1 gene were computed at synonymous and nonsynonymous sites separately. For nonantigenic sites, the nucleotide diversities were larger at synonymous sites than at nonsynonymous sites. This is consistent with the neutral theory of molecular evolution. For antigenic sites, however, the nucleotide diversities at nonsynonymous sites were larger than those at synonymous sites. These results suggest that positive selection operates on antigenic sites of the HA1 gene of human influenza A viruses (H1 subtype).

Original languageEnglish (US)
Pages (from-to)8388-8392
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number18
DOIs
StatePublished - Aug 30 1994

Keywords

  • neutral theory of molecular evolution
  • positive selection
  • synonymous and nonsynonymous substitutions

ASJC Scopus subject areas

  • General

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