Solid phase synthesis of peptide hydroxamic acids on poly(ethylene glycol)-based support

Marta Cal, Mariusz Jaremko, Lukasz Jaremko, Piotr Stefanowicz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A novel resin designed for solid-phase synthesis of peptide hydroxamic acids (PHA) combining the trityl linker with poly(ethylene glycol)-based support, ChemMatrix® type, is described. The synthesis of PHA can be performed according to a standard protocol, providing products in excellent purity and reasonable yields.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalJournal of Peptide Science
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • ChemMatrix resin
  • Hydroxamic acid
  • Modified peptide
  • Solid phase

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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