Solid-Phase Synthesis of Oligosaccharides. I. Preparation of the Solid Support. Poly[p-(1-propen-3-ol-1-yl)styrene]

Jean Frechet, Conrad Schuerch

Research output: Contribution to journalArticlepeer-review

290 Scopus citations

Abstract

Solid-phase synthesis of oligosaccharides requires the use of a saccharide derivative with a reactive leaving group at C-1, one hydroxyl protected by a readily removable blocking group, the remaining hydroxyls protected by a stable blocking group, and a resin which can be separated from the formed oligosaccharide derivative without removing the alcoholic substituents. A polystyrene resin with allyl alcohol functional groups has been prepared and a procedure for the solid-phase synthesis of oligosaccharides has been tested with an appropriately substituted glycosyl halide.

Original languageEnglish (US)
Pages (from-to)492-496
Number of pages5
JournalJournal of the American Chemical Society
Volume93
Issue number2
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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